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Madikeri (Mercara) is about 140km southeast of Mangalore. There are regular  bus (KRSTC) services between the two places.

If you are driving, take the NH48 (popularly, Bangalore-Mangalore highway) first from Mangalore.  At Mani leave the highway and take the right diversion to Puttur.  About 36km later you'll cross the Sullia town.

In about 30 minutes from Sullia, you'll reach the Sampaje Ghat section where the road makes zigzag around the hilly terrain. It typically takes about 4+ hours to cover the distance between Madikeri and Mangalore.

By the way, if you are heading towards Kukke Subrahmaniya, see Mangalore to Kukke Subrahmaniya route map and driving directions.

Also if you destination in Coorg is southern part of Coorg, like Virajpet, you can consider the Panathur-Karike route . This goes via Bhagamandala (from where a detour can take you to Talakaveri ).

To take this route drive all the way to Sullia. As you exit Sullia town, take the right diversion that goes towards Panathur.

The road now onwards, till you reach Bhaganandala (about 50km) is quite curvy and through forest region. Also you'll be entering Kerala state briefly at Panathur before taking the diversion towards Karike.

The stretch is pretty scenic and traffic is thin.

Mangalore to Coorg by Train: Coorg doesn't have a railway route. However there is a rail route goes around the region, especially connecting Mangalore with Hassan via Subrahmaniya.

See the options to travel to Coorg by train.